Dataset Information
Nguyen2013 - Dynamic model of HIF regulation in hypoxia (reduced model)
Ontology highlight
ABSTRACT: Its a mathematcial model explaining regulation of HIF via FIH and oxygen. Model is further validated by Experimental data and various hypothesis has been tested on the same.
ORGANISM(S): Homo sapiens
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL1912100005 | biostudies-other |
SECONDARY ACCESSION(S): 23390316
REPOSITORIES: biostudies-other
Publications
A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.
Journal of cell science 20130206 Pt 6
Activation of the hypoxia-inducible factor (HIF) pathway is a critical step in the transcriptional response to hypoxia. Although many of the key proteins involved have been characterised, the dynamics of their interactions in generating this response remain unclear. In the present study, we have generated a comprehensive mathematical model of the HIF-1α pathway based on core validated components and dynamic experimental data, and confirm the previously described connections within the predicted ...[more]
