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Mazet2020 - model of the PI cycle

ABSTRACT: <notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>PI cycle Core Model Global Quantities = free + bound PL for PI, PIP2, PI4P, PIP3, PI34P2, DAG, PA.For PI initial quantity added in GQ is in organelle membranesNB: all labeled [xxgl] in plotsselect L.GPCR for GPCR simulations in Eventsselect R for GqPCR receptor number simulationsrelevant plots = Core - IP3-DAG - PI3K-GPCRNB: Built using Particle Numbersflux are not properly calculated (enzymes are not written as modifiers)</pre> </body> </notes>

SUBMITTER: Francoise M. Mazet 

PROVIDER: MODEL2006300001 | biostudies-other |

SECONDARY ACCESSION(S): 32764630

REPOSITORIES: biostudies-other

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A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data.

Mazet Francoise F   Tindall Marcus J MJ   Gibbins Jonathan M JM   Fry Michael J MJ  

Scientific reports 20200806 1

The phosphatidylinositol (PI) cycle is central to eukaryotic cell signaling. Its complexity, due to the number of reactions and lipid and inositol phosphate intermediates involved makes it difficult to analyze experimentally. Computational modelling approaches are seen as a way forward to elucidate complex biological regulatory mechanisms when this cannot be achieved solely through experimental approaches. Whilst mathematical modelling is well established in informing biological systems, many mo  ...[more]

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Models Mazet2020 - model of the PI cycle
2020-06-30 | MODEL2006300001 | BioModels