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Lu2021-Genome scale metabolic model for yeast species of clade CUG-Ala


ABSTRACT: This is genome-scale metabolic model of Pachysolen tannophilus as the representative yeast species for the clade CUG-Ala. This model was generated through homology search using a fungal pan-GEM largely based on Yeast8 for Saccharomyces cerevisiae, in addition to manual curation. This model has been produced by the Yeast-Species-GEMs project from Sysbio (www.sysbio.se). This is model version 1.0.0 accompanying the publication (DOI: 10.15252/msb.202110427), currently hosted on BioModels Database and identified by MODEL2109130004. Further curations of this model will be tracked in the GitHub repository: https://github.com/SysBioChalmers/Yeast-Species-GEMs Models for species of the same clade includes: Nakazawaea peltata; Pachysolen tannophilus; Peterozyma xylosa; Peterozyma toletana; Nakazawaea holstii. These models are available in the zip file. To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to MIT License for more information.

SUBMITTER: feiran 

PROVIDER: MODEL2109130004 | biostudies-other |

SECONDARY ACCESSION(S): 10.15252/msb.202110427

REPOSITORIES: biostudies-other

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Publications

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.

Takahashi Hidekazu H   McCaffery J Michael JM   Irizarry Rafael A RA   Boeke Jef D JD  

Molecular cell 20060701 2


Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, as they are important not only for carbon metabolism but also are shown here to supply the acetyl-CoA for histone acetylation by histone acetyltransferases (HATs). acs2-Ts mutants exhibit global histone deacetylation, transcriptional defects, and synthetic growth defects with HAT mutants at high temperatures. In glycerol with ethanol, Acs1p is an alternate  ...[more]

Publication: 1/358

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