Unknown

Dataset Information

0

Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance

ABSTRACT: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans. Bilirubin has antioxidant and anti-inflammatory activities and may also regulate insulin signaling and peroxisome proliferator-activated receptor alpha (PPARα) activity. However, a causal link between bilirubin and metabolic diseases remains to be established. Here, we used the global Bvra gene knockout (Bvra–/–) mouse as a model of deficiency in bilirubin to assess its role in metabolic diseases.

ORGANISM(S): Mus musculus (mouse)

SUBMITTER:  

PROVIDER: S-BSST1038 | biostudies-other |

REPOSITORIES: biostudies-other

Json Xml

Similar Datasets

Unknown Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance.
| S-EPMC8498001 | biostudies-literature
Unknown Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance.
| S-EPMC7399260 | biostudies-literature
Unknown Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance.
| S-EPMC5860441 | biostudies-literature
Unknown Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice.
| S-EPMC4837354 | biostudies-literature
Unknown Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.
| S-EPMC3205235 | biostudies-literature
Unknown Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice.
| S-EPMC6911300 | biostudies-literature
Unknown Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice.
| S-EPMC8246594 | biostudies-literature
Unknown Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis.
| S-EPMC4239060 | biostudies-literature
Unknown Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.
| S-EPMC2040460 | biostudies-other
Unknown Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.
| S-EPMC2874692 | biostudies-literature