Conjugation with Tris decreases the risk of ketoprofen-induced mucosal damage - databases

ABSTRACT: The non-steroid anti-inflammatory drug ketoprofen (Ket) has haemorrhagic side-effects in the upper GI tract. Our aims were thus to develop a new compound from Ket and Tris precursors and compare mucosal effects of Ket and Ket-Tris in a rat model of colitis and in healthy animals. Further, we tested the hypothesis that GI methane generation is associated with the inflammatory activation under these conditions.

ORGANISM(S): Rattus norvegicus (brown rat)

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PROVIDER: S-BSST1132 | biostudies-other |

REPOSITORIES: biostudies-other