Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody

ABSTRACT: Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening disease caused by infection with a novel bunyavirus (SFTSV). However, the existence of multiple SFTSV genotypes presents a significant challenge for developing therapeutic antibodies targeting SFTSV. We provided compelling evidence for the involvement of the PD-1/PD-L1 pathway in the acute infection caused by SFTSV, while demonstrating the potent inhibitory effect of our novel anti-PD1 nanobody, NbP45, against SFTSV infection in vitro and in SFTSV-infected NCG-HuPBL mouse model.

ORGANISM(S): Mus musculus (mouse)

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PROVIDER: S-BSST1245 | biostudies-other |

REPOSITORIES: biostudies-other