The transcription factor IRF-5 is an essential metabolic checkpoint in CD8 T cells during chronic infection.

ABSTRACT: Numerous transcription factors are involved in promoting an intricate gene expression program that leads to CD8 T cell exhaustion. Here, we found that the transcription factor IRF-5 is involved in limiting functional exhaustion of murine CD8 T cells by regulating the cell cycle and contributing to sustaining the mitochondrial functions and oxidative phosphorylation during the chronic stage of LCMV Cl13 infection. CD8 T cells lacking IRF-5 display reduced survival capacity and show increased signs of functional exhaustion during the chronic stage of infection. IRF-5-deficiency also resulted in a severely defective lipid metabolism, in an increased mitochondrial ROS production, and in the reduced capacity to produce ATP. Additionally, we observed increased lipid peroxidation in CD8 T cells l

ORGANISM(S): Mus musculus (mouse)

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PROVIDER: S-BSST1936 | biostudies-other |

REPOSITORIES: biostudies-other