TGFb-facilitated optic fissure fusion and the necessity of locally induced BMP antagonism during this process

ABSTRACT: The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children. Although many genes were linked to coloboma, the process of optic fissure fusion is still little appreciated, especially on a molecular level. We identified a coloboma in mice with a targeted inactivation of the transforming growth factor beta 2 (TGFb2). Notably, here the optic fissure margins got in touch, however, failed to fuse. Transcriptomic analyses indicated an affected remodelling of the extracellular matrix (ECM) as underlying mechanism. TGFb is well known for its ECM remodelling capacity, but it is at the same time often inhibited by Bone Morphogenetic Protein (BMP) signalling. Notab

SUBMITTER: Juan L. Mateo 

PROVIDER: S-BSST80 | biostudies-other |

REPOSITORIES: biostudies-other