Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer

ABSTRACT: Pancreatobiliary cancers have among the highest mortality rates of any cancer type. Discovering the full spectrum of molecular genetic alterations may suggest new avenues for therapy. To catalogue genomic alterations, we carried out array-based genomic profiling of 31 exocrine pancreatic cancers and 6 distal bile duct cancers, expanded as xenografts to enrich the tumor cell fraction. We identified numerous focal DNA amplifications and deletions, including in 19% of pancreatobiliary cases gain at cytoband 18q11.2, a locus uncommonly amplified in other tumor types. The smallest shared amplification at 18q11.2 included GATA6, a transcriptional regulator previously linked to normal pancreas development. When amplified, GATA6 was overexpressed at both the mRNA and protein level, and strong

ORGANISM(S): Homo sapiens

SUBMITTER: Kwei KA 

PROVIDER: S-ECPF-GEOD-11152 | biostudies-other | 2008 May

REPOSITORIES: biostudies-other