Transcription profiling of human basal-like breast cancer - in vitro and in vivo Analysis of B-Myb

ABSTRACT: The basal-like breast cancer subtype portends a poor clinical prognosis, and a defining feature of this subtype is the high expression of genes in the “proliferation signature”. B-Myb, a member of the MYB protein family of transcription factors, is highly expressed in the proliferation signature and is amplified and overexpressed in a variety of tumor types, including breast. In this report we demonstrated that B-Myb is highly expressed in basal-like breast cancer relative to the other subtypes, and B-Myb expression alone is prognostic. We also identified an association between a nonsynonymous B-Myb germline variant (S427G, rs2070235) and an increased risk of having a basal-like breast cancer among patients with breast cancer. The expression of B-Myb, or the S427G variant, was manipulat

ORGANISM(S): Homo sapiens

SUBMITTER: Thorner AR 

PROVIDER: S-ECPF-GEOD-11429 | biostudies-other | 2009 Feb

REPOSITORIES: biostudies-other