High-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes

ABSTRACT: Inflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array-comparative genomic hybridization, and mRNA expression profiles of 197 samples using whole-genome microarrays. Genomic profiles of IBCs were as heterogeneous as those of nIBCs, and globally relatively close. However, IBCs showed more frequent “complex” patterns and a higher percentage of genes with CNAs per sample. The number of altered regions was similar in both types, although some regions were altered more frequently and/or with higher amplitude in IBCs. Many genes were similarly altered in both types; however, more

ORGANISM(S): Homo sapiens

SUBMITTER: Bekhouche I 

PROVIDER: S-ECPF-GEOD-23720 | biostudies-other | 2011

REPOSITORIES: biostudies-other