Transcription profiling by array of human gonadotrope and null cell pituitary tumors

ABSTRACT: Gonadotrope or null cell pituitary tumors present clinically with signs of hypogonadism and hypopituitarism, together with visual disturbances due to mass effects. Since there are no medical therapies, surgery and/or radiation are the only therapeutic options. To identify dysregulated genes and/or pathways that may play a role in tumorigenesis and/ or progression, molecular profiling was performed on 14 gonadotrope tumors and 9 normal human pituitaries from autopsy samples. Principle component analysis (PCA) revealed clear discrimination between tumor and normal pituitary gene expression profiles. Bioinformatic analysis identified specific genes and pathways that were highly differentially regulated, including a cohort of putative downstream effectors of p53 were repressed in gonadotrop

ORGANISM(S): Homo sapiens

SUBMITTER: Michaelis KA 

PROVIDER: S-ECPF-GEOD-26966 | biostudies-other | 2011 Oct

REPOSITORIES: biostudies-other