Expression data from melanoma cells grown under neural crest cell culture conditions (spheroid cells) versus under classical adherent conditions (adherent cells) - 2 different specimens of melanoma tumors

ABSTRACT: Summary: Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function Background: The aggressiveness of melanoma tumors is likely to rely on their well-recognized heterogeneity and plasticity. Melanoma comprises multi subpopulations of cancer cells some of which may possess stem cell-like properties supporting the notion of plasticity. Although useful for certain tumors, the use of the sphere-formation assay to identify stem cell-like or tumor initiating cells subpopulations in human melanoma has been recently challenged. Our study reveals that this assay predicts a functional phenotype associated with aggressive behavior of tumor cells. Methodology/Principal Findings: We analyzed the molecular and funct

ORGANISM(S): Homo sapiens

SUBMITTER: Al-Daccak Reem 

PROVIDER: S-ECPF-GEOD-26980 | biostudies-other |

REPOSITORIES: biostudies-other