RNA-seq of 675 commonly used human cancer cell lines

ABSTRACT: "Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic response1. Although substantial effort has been directed to defining the genomic constitution of cancer cell line panels24, the transcriptome which represents the active program of a cell remains understudied. Here, we describe RNA sequencing and SNP array analysis of 675 commonly used human cancer cell lines. We explore numerous transcriptome features including coding and non-coding gene expression, transcribed mutations, gene fusion and expression of non-human sequences. Aside from many known aberrations we find new surprising characteristics, including more than 2200 unique fusion gene pairs representing a vast, testable repertoire of oncogenic fusions, many of which

ORGANISM(S): Homo sapiens

SUBMITTER: Klijn C 

PROVIDER: S-ECPF-MTAB-2706 | biostudies-other | 2015 Mar

REPOSITORIES: biostudies-other