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Beta-adrenergic induction of a cysteine-proteinase-inhibitor mRNA in rat salivary glands.


ABSTRACT: Transcripts encoding the cysteine-proteinase inhibitor rat cystatin S are induced in submandibular and parotid glands by the beta-adrenergic agonist isoproterenol (isoprenaline). High levels of cystatin S mRNA persist in glands of chronically treated animals for 6 days after discontinuation of the catecholamine, indicating a long half-life of the mRNA. Post-transcriptionally the size of the mRNA decreases, owing to a shortening of the poly(A) tail.

SUBMITTER: Shaw PA 

PROVIDER: S-EPMC1135642 | biostudies-other | 1989 Feb

REPOSITORIES: biostudies-other

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