Dataset Information
A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli.
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ABSTRACT:
SUBMITTER: Jager W
PROVIDER: S-EPMC178988 | biostudies-other | 1997 Apr
REPOSITORIES: biostudies-other
Publications
A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli.
Journal of bacteriology 19970401 7
A chromosomal DNA fragment from the erythromycin-sensitive bacterium Corynebacterium glutamicum ATCC 13032 was shown to mediate resistance against erythromycin, tetracycline, puromycin, and bleomycin in Escherichia coli. Multicopy cloning of the fragment did not cause a resistance phenotype in C. glutamicum. The corresponding gene encodes a hydrophobic protein with 12 potential transmembrane-spanning ex-helical segments showing similarity to drug-H+ antiporters. ...[more]