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Osteochondral autografting (mosaicplasty) in grade IV cartilage defects in the knee joint: 2- to 7-year results.

ABSTRACT: The use of autologous osteochondral grafts (mosaicplasty) to repair articular cartilage defects is a well-established technique. Between 1998 and 2003, 19 patients with grade IV cartilage defects in the knee joint were treated by mosaicplasty. The average age of these 13 men (68%) and six women (32%) was 33.1 years (20-46). The mean follow-up was 32.4 months (84-24). The mean preoperative and postoperative Lysholm score was 45.8 (21-60) and 87.5 (74-100), respectively (p<0.001). Postoperative evaluation showed significant improvement. The results at the last follow-up were excellent in seven patients (27%), good in 11 patients (58%) and fair in one patient (15%). Preoperative complaints of pain, crepitation and locking disappeared in all patients. Magnetic resonance imaging (MRI) examination at the last follow-up visit revealed that congruency was restored in 16 (84.2%) without any signs of fissuring or delamination but in three patients (15.8%) a 1-mm difference between graft and recipient surface was detected. No complications were observed in the patients. Mosaicplasty is a really effective method of treatment for grade IV cartilage lesions in the knee joint.

SUBMITTER: Ozturk A

PROVIDER: S-EPMC2532091 | biostudies-other | 2006 Jun

REPOSITORIES: biostudies-other

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Project description:IntroductionAutologous chondrocyte implantation (ACI) is a crucial method for the treatment of defects in articular cartilage. However, the extant methods for the preparation of autologous chondrocyte patch are relatively complicated and money-consuming. Therefore, an efficient, reliable, easy-to-follow, and cost-effective technique is needed to overcome constraints. This case report aims to introduce an autologous chondrocyte patch fabrication technique to repair knee joint cartilage defects and report our typical cases with a 2-year follow-up.Case presentationWe described four cases in which patients complained of knee joint pain. According to radiological examination, the patients were diagnosed as knee joint cartilage defect. Arthroscopy and autologous chondrocyte patch implantation were performed as well as a 2-year follow up of patients. The autologous chondrocyte patch for knee joint cartilage repair was fabricated using a "sandwich" technique. The preoperative and postoperative knee function was evaluated by four subjective evaluation systems. MRI was performed for all patients to achieve more intuitionistic observation of the postoperative radiological changes of defect sites. The quality of repaired tissue was evaluated by Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART). Postoperative follow-up showed improvement in clinical and MOCART scores for all patients. However, one patient complained of knee joint pain after walking for a long time or recreational activities from 12- to 18-month postoperatively. The location of pain for this patient was not in accordance with the location of cartilage defect.ConclusionThe patients undergoing autologous chondrocyte patch implantation demonstrated clinical improvement and good quality of repaired tissue postoperatively. The procedure is an efficient and cost-effective treatment for knee joint cartilage defect in this report. In addition, patients with osteoarthritis carry the risk of a poor outcome after the procedure, and whether to have a procedure should be considered carefully.

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Osteochondral autografting (mosaicplasty) in grade IV cartilage defects in the knee joint: 2- to 7-year results.

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