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Genomic islands of uropathogenic Escherichia coli contribute to virulence.

ABSTRACT: Uropathogenic Escherichia coli (UPEC) strain CFT073 contains 13 large genomic islands ranging in size from 32 kb to 123 kb. Eleven of these genomic islands were individually deleted from the genome, and nine isogenic mutants were tested for their ability to colonize the CBA/J mouse model of ascending urinary tract infection. Three genomic island mutants (Delta PAI-aspV, Delta PAI-metV, and Delta PAI-asnT) were significantly outcompeted by wild-type CFT073 in the bladders and/or kidneys following transurethral cochallenge (P

SUBMITTER: Lloyd AL 

PROVIDER: S-EPMC2681901 | biostudies-other | 2009 Jun

REPOSITORIES: biostudies-other

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Genomic islands of uropathogenic Escherichia coli contribute to virulence.

Lloyd Amanda L AL   Henderson Tiffany A TA   Vigil Patrick D PD   Mobley Harry L T HL  

Journal of bacteriology 20090327 11

Uropathogenic Escherichia coli (UPEC) strain CFT073 contains 13 large genomic islands ranging in size from 32 kb to 123 kb. Eleven of these genomic islands were individually deleted from the genome, and nine isogenic mutants were tested for their ability to colonize the CBA/J mouse model of ascending urinary tract infection. Three genomic island mutants (Delta PAI-aspV, Delta PAI-metV, and Delta PAI-asnT) were significantly outcompeted by wild-type CFT073 in the bladders and/or kidneys following  ...[more]

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