Ontology highlight
ABSTRACT:
SUBMITTER: Matsuo N
PROVIDER: S-EPMC2692967 | biostudies-other | 2008 Feb
REPOSITORIES: biostudies-other
Science (New York, N.Y.) 20080201 5866
The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selecti ...[more]