Ontology highlight
ABSTRACT:
SUBMITTER: Basu D
PROVIDER: S-EPMC2731897 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
Nucleic acids research 20090615 15
The Mycobacterium tuberculosis genome sequence reveals remarkable absence of many nucleoid-associated proteins (NAPs), such as HNS, Hfq or DPS. In order to characterize the nucleoids of M. tuberculosis, we have attempted to identify NAPs, and report an interesting finding that a chaperonin-homolog, GroEL1, is nucleoid associated. We report that M. tuberculosis GroEL1 binds DNA with low specificity but high affinity, suggesting that it might have naturally evolved to bind DNA. We are able to demo ...[more]