Ontology highlight
ABSTRACT:
SUBMITTER: Rudnick PA
PROVIDER: S-EPMC2830836 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Molecular & cellular proteomics : MCP 20091016 2
A major unmet need in LC-MS/MS-based proteomics analyses is a set of tools for quantitative assessment of system performance and evaluation of technical variability. Here we describe 46 system performance metrics for monitoring chromatographic performance, electrospray source stability, MS1 and MS2 signals, dynamic sampling of ions for MS/MS, and peptide identification. Applied to data sets from replicate LC-MS/MS analyses, these metrics displayed consistent, reasonable responses to controlled p ...[more]