Ontology highlight
ABSTRACT:
SUBMITTER: Walseng E
PROVIDER: S-EPMC3009902 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20101103 53
The expression of MHC class II (MHC-II) on the surface of antigen-presenting cells, such as dendritic cells (DCs), is tightly regulated during cellular activation. Many cells, including DCs, are activated following stimulation of innate Toll-like receptors (TLRs) by products of microorganisms. In the resting (immature) state, MHC-II is ubiquitinated in immature DCs and is rapidly degraded; however, after activation of these cells with MyD88-dependent TLR ligands, MHC-II ubiquitination is blocked ...[more]