Ontology highlight
ABSTRACT:
SUBMITTER: Dey BK
PROVIDER: S-EPMC3019853 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Molecular and cellular biology 20101101 1
The Pax7 transcription factor is required for muscle satellite cell biogenesis and specification of the myogenic precursor lineage. Pax7 is expressed in proliferating myoblasts but is rapidly downregulated during differentiation. Here we report that miR-206 and -486 are induced during myoblast differentiation and downregulate Pax7 by directly targeting its 3' untranslated region (UTR). Expression of either of these microRNAs in myoblasts accelerates differentiation, whereas inhibition of these m ...[more]