Ontology highlight
ABSTRACT:
SUBMITTER: Robinson DR
PROVIDER: S-EPMC3233654 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Nature medicine 20111120 12
Breast cancer is a heterogeneous disease that has a wide range of molecular aberrations and clinical outcomes. Here we used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes encoding microtubule-associated serine-threonine kinase (MAST) and members of the Notch ...[more]