Dataset Information
Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer
Ontology highlight
ABSTRACT: Paired-end transcriptome sequencing was performed on a panel of breast cancer cell lines and tissues and a set of benign cell line and tissue controls. Analyses of the paired end sequences were performed and chimeric transcripts derived from gene rearrangement events were identified. Sequencing was performed on Illumina GAII and HiSeq 2000 platforms with read lengths from 40 to 100 bases.
PROVIDER: phs000513.v1.p1 | EGA |
REPOSITORIES: EGA
Publications
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Nature medicine 20111120 12
Breast cancer is a heterogeneous disease that has a wide range of molecular aberrations and clinical outcomes. Here we used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes encoding microtubule-associated serine-threonine kinase (MAST) and members of the Notch ...[more]
