Ontology highlight
ABSTRACT:
SUBMITTER: Kosaka N
PROVIDER: S-EPMC3256909 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Kosaka Nobuyoshi N Iguchi Haruhisa H Yoshioka Yusuke Y Hagiwara Keitaro K Takeshita Fumitaka F Ochiya Takahiro T
The Journal of biological chemistry 20111128 2
Normal epithelial cells regulate the secretion of autocrine and paracrine factors that prevent aberrant growth of neighboring cells, leading to healthy development and normal metabolism. One reason for tumor initiation is considered to be a failure of this homeostatic cell competitive system. Here we identify tumor-suppressive microRNAs (miRNAs) secreted by normal cells as anti-proliferative signal entities. Culture supernatant of normal epithelial prostate PNT-2 cells attenuated proliferation o ...[more]