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An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.

ABSTRACT: The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.

SUBMITTER: Nicolis S 

PROVIDER: S-EPMC328889 | biostudies-other | 1991 Oct

REPOSITORIES: biostudies-other

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An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.

Nicolis S S   Bertini C C   Ronchi A A   Crotta S S   Lanfranco L L   Moroni E E   Giglioni B B   Ottolenghi S S  

Nucleic acids research 19911001 19

The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site. ...[more]

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