Ontology highlight
ABSTRACT:
SUBMITTER: Cuddapah S
PROVIDER: S-EPMC3343078 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Cuddapah Suresh S Roh Tae-Young TY Cui Kairong K Jose Cynthia C CC Fuller Margaret T MT Zhao Keji K Chen Xin X
PloS one 20120503 5
Polycomb group (PcG) proteins are key chromatin regulators implicated in multiple processes including embryonic development, tissue homeostasis, genomic imprinting, X-chromosome inactivation, and germ cell differentiation. The PcG proteins recognize target genomic loci through cis DNA sequences known as Polycomb Response Elements (PREs), which are well characterized in Drosophila. However, mammalian PREs have been elusive until two groups reported putative mammalian PREs recently. Consistent wit ...[more]