Ontology highlight
ABSTRACT:
SUBMITTER: Dai Q
PROVIDER: S-EPMC3408147 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20120430 30
Protein phosphorylation plays an important role in the regulation of self-renewal and differentiation of embryonic stem cells. However, the responsible intracellular kinases are not well characterized. Here, we discovered that cyclin K protein was highly expressed in pluripotent embryonic stem cells but low in their differentiated derivatives or tissue-specific stem cells. Upon cell differentiation, the level of cyclin K protein was decreased. Furthermore, knockdown of cyclin K led to cell diffe ...[more]