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Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats.

ABSTRACT: BACKGROUND: The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized. METHODS: We compared an obese spontaneously hypertensive rat model (SHR-ob) with lean spontaneously hypertensive rats (SHR-lean) and normotensive controls (Ctr). LV-function was investigated by cardiac magnetic resonance imaging and invasive LV-pressure measurements. LV-interstitial fibrosis was quantified and protein levels of phospholamban (PLB), Serca2a and glucose transporters (GLUT1 and GLUT4) were determined by immunohistochemistry. RESULTS: Systolic blood pressure was similar in SHR-lean and SHR-ob (252?±?7 vs. 242?±?7 mmHg, p?=?0.398) but was higher when compared to Ctr (155?±?2 mmHg, p?

SUBMITTER: Linz D 

PROVIDER: S-EPMC3508805 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats.

Linz Dominik D   Hohl Mathias M   Mahfoud Felix F   Reil Jan-Christian JC   Linz Wolfgang W   Hübschle Thomas T   Juretschke Hans-Paul HP   Neumann-Häflin Claudia C   Rütten Hartmut H   Böhm Michael M  

Journal of translational medicine 20120910

<h4>Background</h4>The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized.<h4>Methods</h4>We compared an obese spontaneously hypertensive rat model (SHR-ob) with lean spontaneously hypertensive rats (SHR-lean) and normotensive controls (Ctr). LV-function was investigated by cardiac magnetic resonance imaging and invasive LV-pressure measurements. LV-interstitial fibrosis was quantified and protein  ...[more]

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