Ontology highlight
ABSTRACT:
SUBMITTER: Mulay SR
PROVIDER: S-EPMC3533282 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
The Journal of clinical investigation 20121210 1
Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying pathological mechanisms remain elusive. Other crystallopathies, such as gout, atherosclerosis, and asbestosis, trigger inflammation and tissue remodeling by inducing IL-1β secretion, leading us to hypothesize that CaOx crystals may induce inflammation in a similar manner. In mice, intrarenal CaOx deposition induced tubular damage, cytokine ...[more]