Ontology highlight
ABSTRACT:
SUBMITTER: Parks BW
PROVIDER: S-EPMC3545283 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Cell metabolism 20130101 1
Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) di ...[more]