Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh YT
PROVIDER: S-EPMC3591800 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Blood 20130114 10
Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4 (alpha4) mediates stromal adhesion of normal and malignant B-cell precursors, and according to gene expression analyses from 207 children with minimal residual disease, is highly associated with poorest outcome. We tested whether interference with alpha4-mediated stromal adhesion might be a new ALL treatment. Two models of leukemia were us ...[more]