Ontology highlight
ABSTRACT:
SUBMITTER: Davidson L
PROVIDER: S-EPMC3737548 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Nucleic acids research 20130528 14
Splicing of human pre-mRNA is reciprocally coupled to 3' end formation by terminal exon definition, which occurs co-transcriptionally. It is required for the final maturation of most human pre-mRNAs and is therefore important to understand. We have used several strategies to block splicing at specific stages in vivo and studied their effect on 3' end formation. We demonstrate that a terminal splice acceptor site is essential to establish coupling with the poly(A) signal in a chromosomally integr ...[more]