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Evidence for the involvement of Lfc and Tctex-1 in axon formation.

ABSTRACT: RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.

SUBMITTER: Conde C 

PROVIDER: S-EPMC3845415 | biostudies-other | 2010 May

REPOSITORIES: biostudies-other

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Evidence for the involvement of Lfc and Tctex-1 in axon formation.

Conde Cecilia C   Arias Cristina C   Robin Maria M   Li Aiqun A   Saito Masaki M   Chuang Jen-Zen JZ   Nairn Angus C AC   Sung Ching-Hwa CH   Cáceres Alfredo A  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100501 19

RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreas  ...[more]