Ontology highlight
ABSTRACT:
SUBMITTER: Dixon JL
PROVIDER: S-EPMC3856687 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Dixon Joseph L JL Kim Youn-Kyung YK Brinker Anita A Quadro Loredana L
Biochimica et biophysica acta 20130827 1
We provide novel insights into the function(s) of β-carotene-15,15'-oxygenase (CMOI) during embryogenesis. By performing in vivo and in vitro experiments, we showed that CMOI influences not only lecithin:retinol acyltransferase but also acyl CoA:retinol acyltransferase reaction in the developing tissues at mid-gestation. In addition, LC/MS lipidomics analysis of the CMOI-/- embryos showed reduced levels of four phosphatidylcholine and three phosphatidylethanolamine acyl chain species, and of eig ...[more]