Ontology highlight
ABSTRACT:
SUBMITTER: Sunyer JO
PROVIDER: S-EPMC38709 | biostudies-other | 1996 Aug
REPOSITORIES: biostudies-other
Sunyer J O JO Zarkadis I K IK Sahu A A Lambris J D JD
Proceedings of the National Academy of Sciences of the United States of America 19960801 16
In all other species analyzed to date, the functionally active form of complement component C3 exists as the product of a single gene. We have now identified and characterized three functional C3 proteins (C3-1, C3-3, and C3-4) in trout that are the products of at least two distinct C3 genes. All three proteins are composed of an alpha-and a beta-chain and contain a thioester bond in the alpha-chain. However, they differ in their electrophoretic mobility, glycosylation, reactivity with monospeci ...[more]