Ontology highlight
ABSTRACT:
SUBMITTER: Ronkainen J
PROVIDER: S-EPMC4363842 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Scientific reports 20150318
Common variants of human fat mass- and obesity-associated gene Fto have been linked with higher body mass index, but the biological explanation for the link has remained obscure. Recent findings suggest that these variants affect the homeobox protein IRX3. Here we report that FTO has a role in white adipose tissue which modifies its response to high-fat feeding. Wild type and Fto-deficient mice were exposed to standard or high-fat diet for 16 weeks after which metabolism, behavior and white adip ...[more]