Ontology highlight
ABSTRACT:
SUBMITTER: Danan-Gotthold M
PROVIDER: S-EPMC4446417 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Danan-Gotthold Miri M Golan-Gerstl Regina R Eisenberg Eli E Meir Keren K Karni Rotem R Levanon Erez Y EY
Nucleic acids research 20150423 10
Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in multiple cancer types are enriched for such driver events. Here, we studied splicing alterations in hundreds of matched tumor and normal RNA-seq samples of eight solid cancer types. We found hundreds of ...[more]