Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka Y
PROVIDER: S-EPMC4471828 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Stem cell reports 20150521 6
Reprogramming of somatic cells produces induced pluripotent stem cells (iPSCs) that are invaluable resources for biomedical research. Here, we extended the previous transcriptome studies by performing RNA-seq on cells defined by a combination of multiple cellular surface markers. We found that transcriptome changes during early reprogramming occur independently from the opening of closed chromatin by OCT4, SOX2, KLF4, and MYC (OSKM). Furthermore, our data identify multiple spliced forms of genes ...[more]