Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa.

ABSTRACT: The intestinal mucosa squares the circle by allowing efficient nutrient absorption while generating a firm barrier toward the enteric microbiota, enteropathogenic microorganisms and high luminal concentrations of potent immunostimulatory molecules. The mucus layer together with local antimicrobial and anti-inflammatory peptides significantly contribute to this ability. Here we summarize the recent progress made to better understand the critical importance of this dynamic, complex and highly structured anti-inflammatory and antimicrobial barrier.

SUBMITTER: Dupont A 

PROVIDER: S-EPMC4615892 | biostudies-other | 2014

REPOSITORIES: biostudies-other