Ontology highlight
ABSTRACT:
SUBMITTER: You J
PROVIDER: S-EPMC4633902 | biostudies-other | 2015
REPOSITORIES: biostudies-other
American journal of cancer research 20150815 9
Increasing evidence reveals that deregulation of miRNAs contributes to carcinogenesis of the human non-small cell lung cancer (NSCLC). Our study discovered that the expression of miR-449a was markedly decreased in NSCLC cells with high metastatic capacity and tissues of positive lymph node metastasis. Moreover, our results showed that miR-449a could act as a tumor suppressor by inhibiting the invasion of NSCLC cells in vitro and in vivo. Mechanistically, miR-449a inhibited the expression of MAP2 ...[more]