Ontology highlight
ABSTRACT:
SUBMITTER: Ulyanchenko S
PROVIDER: S-EPMC4819909 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Cell reports 20160317 12
Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent TEC progenitors that can efficiently generate both cortical (c) TECs and medullary (m) TECs. No other adult TEC population tested in this study contains this activity. We demonstrat ...[more]