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DNA damage tolerance branches out toward sister chromatid cohesion.

ABSTRACT: Genome duplication is temporarily coordinated with sister chromatid cohesion and DNA damage tolerance. Recently, we found that replication fork-coupled repriming is important for both optimal cohesion and error-free replication by recombination. The mechanism involved has implications for the etiology of replication-based genetic diseases and cancer.

SUBMITTER: Branzei D 

PROVIDER: S-EPMC4845193 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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