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Flicking the molecular switch underlying MLKL-mediated necroptosis.

ABSTRACT: The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.

SUBMITTER: Hildebrand JM 

PROVIDER: S-EPMC4905300 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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