Ontology highlight
ABSTRACT:
SUBMITTER: Stevens SM
PROVIDER: S-EPMC5064848 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Stevens Sean M SM von Gise Alexander A VanDusen Nathan N Zhou Bin B Pu William T WT
Developmental biology 20160314 2
A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. Here we show that fetal yolk macrophages are recruited to a niche within and just below the epicardium, the mesothelial covering of the heart. The epicardium was required for establis ...[more]