Ontology highlight
ABSTRACT:
SUBMITTER: Janowski AM
PROVIDER: S-EPMC5096827 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Janowski Ann M AM Colegio Oscar R OR Colegio Oscar R OR Hornick Emma E EE McNiff Jennifer M JM Martin Matthew D MD Badovinac Vladimir P VP Norian Lyse A LA Zhang Weizhou W Cassel Suzanne L SL Sutterwala Fayyaz S FS
The Journal of clinical investigation 20160912 10
Members of the NLR family can assemble inflammasome complexes with the adaptor protein ASC and caspase-1 that result in the activation of caspase-1 and the release of IL-1β and IL-18. Although the NLRC4 inflammasome is known to have a protective role in tumorigenesis, there is an increased appreciation for the inflammasome-independent actions of NLRC4. Here, we utilized a syngeneic subcutaneous murine model of B16F10 melanoma to explore the role of NLRC4 in tumor suppression. We found that NLRC4 ...[more]