Ontology highlight
ABSTRACT:
SUBMITTER: Mori T
PROVIDER: S-EPMC5111849 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Experimental animals 20160628 4
IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 ...[more]