Ontology highlight
ABSTRACT:
SUBMITTER: Volk N
PROVIDER: S-EPMC5120368 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Cell reports 20161101 7
MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited in ...[more]