Ontology highlight
ABSTRACT:
SUBMITTER: Sheih A
PROVIDER: S-EPMC5389932 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Sheih A A Parks W C WC Ziegler S F SF
Mucosal immunology 20161012 3
Airway epithelial cells are among the first to encounter inhaled allergens and can initiate allergic responses by producing pro-Th2 innate cytokines. In this study, we investigated the role of epithelial-derived cytokines in sensitization to a clinically relevant allergen, cockroach allergen (CRA). Among the epithelial-derived cytokines, granulocyte macrophage colony-stimulating factor (GM-CSF) had a central role in the initiation of Th2 allergic responses to CRA. We show that initial exposure t ...[more]